Endocrine Abstracts

The treatment of craniopharyngiomas remains controversial, as no prospective randomized study has been performed. Although it is a benign tumour it may be life threatening because of its malignant growth and high recurrence rate. Compared to the general population, patients with this tumour has a 5-9-fold excess of mortality. The recurrence rate of the tumour seems to be dependent on the extent of tumour removal, the patient's age, and time of follow up. Primary radical surger...

Introduction: Hypothalamic damage in craniopharyngiomas (CP) is associated with poor functional outcome. Data on quality of life (QoL) in CP on complete hormone replacement, including GH, is missing. The aim of this study was to assess QoL and neurocognitive function in childhood onset (CO) CP on complete hormone substitution.Methods and design: Forty-two (20 women) patients, aged ≥17 years were recruited from the South Medical Region of Sweden (po...

Introduction: Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. The survival rate is now 85% which emphasis the importance of long-term treatment complications. GH-deficiency (GHD) is common among these survivors treated with cranial radiotherapy (CRT) and chemotherapy. Renal impairment has been reported in childhood (CO) cancer survivors and glomerular filtration rate (GFR) is decreased in hypopituitarism. GH therapy to CO GHD patients has been show...

Preliminary data suggested an increased mortality in a French cohort after childhood somatropin treatment compared to the French reference population1. This cohort included patients (pts) with idiopathic-isolated GH-deficiency (GHD), and a similar cohort is also under follow-up for adult GH-replacement in HypoCCS.We therefore assessed all-cause mortality rates (n/1000 person-years (PY), (95% CI), standardized to the age/gender structure...

Introduction: Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy and accounts for 25% of all childhood cancer. The survival rate is now 85% which emphasis the importance of long-term treatment complications. ALL patients treated with cranial radiotherapy (CRT) and chemotherapy are particularly at risk for GH deficiency (GHD), but little is known about central adrenal deficiency. Partial ACTH deficiency is often asymptomatic, but it may lead to deleteri...